Negative feedback regulation within NO/cGMP pathway attenuates vasodilatory response in renovascular hypertension
نویسندگان
چکیده
منابع مشابه
Negative feedback regulation within NO/cGMP pathway attenuates vasodilatory response in renovascular hypertension
Background Hypertension, the leading risk factor for cardiovascular mortality has been associated with alterations in endotheliumand smooth muscle-dependent vascular relaxation. The NO/cGMP signaling cascade is one of the major pathways that mediate vascular relaxation. In this pathway, the NO receptor guanylyl cyclase (NO-GC) holds a key position by converting the NO signal into cGMP increases...
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ژورنال
عنوان ژورنال: BMC Pharmacology
سال: 2009
ISSN: 1471-2210
DOI: 10.1186/1471-2210-9-s1-p48